Optical Biology Core

Overview of Services

OBC has multiple instruments applicable to biological applications including a Zeiss LSM 780 with 2 photon and incubation, LSM 900 with Airyscan 2, Z1 Mesoscale lightsheet, Elyra 7 with Lattice SIM and SMLM, LSM 700, and a Leica SP8 confocal microscope, as well as additional facilities to support Multi-Dimensional Microscopy (MDM).

The NLOM Lab at the Beckman Laser Institute and Medical Clinic at UC Irvine develops and uses modern biophotonics technologies such as nonlinear optical microscopy for basic research, pre-clinical and clinical applications. One of our major goals related to clinical applications is to use this technology as a non-invasive imaging tool to visualize and understand the microscopic and molecular processes that underlie skin biology. We collaborate closely with the Dermatology Department at UCI to overcome the challenging task related to the clinical translation of multiphoton microscopy. Our Lab is an imaging shared resource for the Chao Family Comprehensive Cancer Center and the Skin Biology Research Center at UCI. Shared instrumentation: Leica SP8 Falcon + coherent anti-Stokes Raman Scattering (CARS)

This is a commercial imaging platform customized to feature the following modalities: confocal fluorescence and two-photon excited fluorescence (TPEF) microscopy, second harmonic generation (SHG), CARS and fluorescence lifetime microscopy. 

 

It is very important to the continued funding of the Chao Family Comprehensive Cancer Center (CFCCC) that the productive collaboration of CFCCC-supported Shared Resources is acknowledged in publications and presentations, and that resulting publications are processed by the National Institutes of Health Manuscript Submission (NIHMS) to obtain a PubMed Central reference number (PMCID), per NIH Public Access Policy.

Please visit the CFCCC website to learn more about Acknowledging the Cancer Center Support Grant (CCSG) and Shared Resources.

 

Direct Link to the UCI Flow Cytometry Core HERE

Leadership

Dr. Adeela Syed|Project Scientist and Manager of Optical Biology Core 

Dr. Rahul Warrior|Associate Professor and Director of Optical Biology Core

Dr. Mihaela Balu|Associate Researcher of NLOM

 

SUPPORT FOR CONFOCAL USERS

Adeela Syed PhD, OBC Manager

Hours: ~9:30am to 4:00pm and by appt.

You can contact Adeela via email (adeelas@uci.edu), or phone (949-824-3856)

 

SUPPORT FOR NONLINEAR OPTICAL MICROSCOPY LAB 

Mihaela Balu, PhD, Associate Researcher

Hours: ~9:30am to 4:00pm and by appt.

You can contact Mihaela via email (mbalu@uci.edu), or phone (949-824-8797)

 

Links and Resources

  1. Optical Biological Core Facilty
  2. Nonlinear Optical Microscopy Lab

Contacts

Name Role Phone Email Location
Dr. Adeela Syed
Project Scientist and Manager of Optical Biology Core
 
949-824-3856
 
adeelas@uci.edu
 
4443 McGaugh Hall